动脉样硬化与随后的认知衰退之间的关联:前性队列研究
Jie Liang1, Yang Pan1, Wenya Zhang1
1School of Nursing Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China.
Journal of the American Heart Association
|November 4, 2024
概括
更显著的动脉样硬化,包括带斑块和冠状动脉化,与语义流性和全球认知的更快的认知衰退有关. 这一发现突显了血管健康对大脑功能的影响.
科学领域:
- 心血管健康 心血管健康
- 神经科学是一个神经科学.
- 衰老研究研究 衰老研究
背景情况:
- 动脉样硬化是一种动脉斑块积累的特征,是老年人群日益关注的问题.
- 亚临床动脉样硬化和认知衰退之间的关系需要进一步研究.
研究的目的:
- 调查基线动脉样硬化与随后在特定领域的短期认知衰退之间的关联.
- 为了确定动脉样硬化标记是否预测认知能力下降的速度.
主要方法:
- 北京研究老龄化和血管 (BRAVE) 研究是一项基于人口的前性队列,包括932名年龄在40至80岁之间的没有痴呆症的成年人.
- 基线动脉样硬化被评估使用心动脉内膜-介质厚度,心动脉斑块,冠状动脉化和脚脉冲波速度.
- 用线性混合模型重新评估和分析认知功能,包括语义流性和全球认知.
主要成果:
- 较高水平的动脉内膜-介质厚度,动脉斑块和手腕-脚脉冲波速与更快的语义流性下降显著相关.
- 升高的冠状动脉化 (≥400) 也预测了语义流性更快的下降.
- 动脉内心介质厚度增加,冠状动脉化和脚脉冲波速与全球认知能力的更快下降相关.
结论:
- 较大的动脉样硬化负担与语义流性加速下降显著相关.
- 血管健康,如动脉样硬化标记所示,在保持全球认知功能随着时间的推移中起着至关重要的作用.
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