患者的维生素D预防?
Jo Sourbron1, Stéphane Auvin2,3,4, Leonor Cabral-Lim5
1Department of Development and Regeneration, Section Pediatric Neurology, University Hospital KU Leuven, Leuven, Belgium.
由于服用抗发作药物,患者 (PWE) 经常出现维生素D缺乏. 建议定期对维生素D进行监测,并对高风险PWE进行骨密度扫描,以预防骨质疏松症和骨折.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 骨质疏松症预防指南在一般人群中有限,通常建议补充维生素D.
- 患有 (PWE) 的人面临的复杂因素增加了维生素D缺乏的风险.
- 对于在PWE中监测骨健康,目前还没有国际指南.
研究的目的:
- 审查PWE中维生素D缺乏风险因素的证据.
- 在PWE人口中确定骨健康问题的高风险群体.
- 为PWE提出最佳的骨健康监测策略.
主要方法:
- 现有证据的叙述性审查.
- 对维生素D缺乏和骨健康受损的风险因素的分析.
- 在PWE人口中确定特定的高风险子组.
主要成果:
- 抗发作药物 (ASM) 的使用,特别是诱导酶的ASM和酸,是导致骨健康不佳和维生素D缺乏的主要危险因素.
- 高风险群体包括残疾人,住院患者,绝经后妇女和服用多种药物的患者.
- 建议采用监测方案,包括实验室检测,骨密度,风险管理和维生素D补充.
结论:
- 定期测量维生素D是PWE的成本效益. 高风险PWE受益于联合维生素D和骨密度计监测.
- 目前的证据不支持所有PWE的持续维生素D补充.
- 患有的儿童需要适合年龄的维生素D摄入量,并对高风险病例进行额外的监测和补充.
更多相关视频
10:46A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
09:57Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
Published on: September 20, 2024
相关概念视频
Antiepileptic Drugs: Potassium Channel Activators
Ezogabine has gained approval as an adjunctive treatment...
Antiepileptic Drugs: Sodium Channel Blockers
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
Antiepileptic Drugs: Calcium Channel Blockers
Calcium channel blockers exert their antiepileptic effects by targeting T-type calcium channels, which are integral to transmitting nerve signals in the central nervous system. These channels allow the passage of calcium ions, which are vital for neuronal communication. By inhibiting T-type calcium channels, calcium channel blockers effectively reduce the release of neurotransmitters and...
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
Antiepileptic Drugs: GABAergic Pathway Potentiators
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
Antiepileptic Drugs: Glutamate Antagonists
