在固体器官移植接收者中对关节动物传播的弗拉维病毒感染进行范围审查
Seohyeon Im1, Fadie Altuame2,3, Isabel H Gonzalez-Bocco4,5
1Department of Internal Medicine, Mass General Brigham-Salem Hospital, Salem, Massachusetts, USA.
概括
在固体器官移植接受者 (SOTRs) 中,关节动物传播的黄状病毒感染的风险更高. 早期诊断和管理对于这些脆弱患者的更好的结果至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 移植医学 移植医学
- 病毒学 病毒学
背景情况:
- 关节动物传播的黄状病毒 (ABF) 是一个日益严重的全球健康问题.
- 固体器官移植接受者 (SOTRs) 可能面临由于免疫抑制而导致ABF感染的风险增加.
研究的目的:
- 审查SOTRs中ABF感染的流行病学,临床特征,诊断,治疗和结果.
- 要突出与此患者群体中的ABF感染相关的具体挑战和风险.
主要方法:
- 对2024年1月25日之前发表的研究进行全面的范围审查.
- 专注于ABF的搜索,包括西尼罗河病毒 (WNV),登革热病毒 (DENV) 和SOTR中的其他病毒.
主要成果:
- 在SOTR中发现了173例WNV病例和386例DENV病例,发烧率很高,精神状况发生变化和神经复杂症.
- 感染WNV的死亡率为23.7%,而DENV的死亡率为4.9%.
- 在某些情况下发生了移植损失或排斥;减少免疫抑制和IVIG是常见的管理策略.
结论:
- 在SOTR中,ABF感染与比一般人群更高的发病率和死亡率有关.
- 需要加强预防措施,及时诊断和针对SOTRs的ABF感染量身定制的治疗方案.
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