肺移植患者感染的流行病学,接受贝拉塔塞普特治疗
Madeleine R Heldman1, Jennifer L Saullo1, Brandon M Menachem2
1Department of Medicine, Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA.
概括
接受贝拉塔塞普治疗的肺移植患者经常经历细胞巨乳病毒 (CMV) 和细菌感染,以及与爱斯坦-巴尔病毒 (EBV) 相关的移植后淋巴增殖性疾病 (PTLD). 需要进一步的研究来了解这些感染风险.
科学领域:
- 免疫学 免疫学 免疫学
- 移植医学 移植医学
- 传染性疾病 传染性疾病
背景情况:
- 贝拉塔塞普是用于预防肺移植接受者 (LuTRs) 排斥的辅助刺激阻塞剂.
- 用贝拉塔塞普治疗的LuTR感染的流行病学需要进行系统的评估.
研究的目的:
- 评估在LuTRs.开始服用belatacept后12个月内发生的感染的发生率和类型.
- 为了比较用于脱敏的贝拉塔塞普与维持免疫抑制的贝拉塔塞普之间的感染率.
主要方法:
- 在2011年1月1日至2022年6月30日期间接受belatacept的成年LuTRs的单中心回顾性研究.
- 在开始服用belatacept后12个月内评估感染情况.
主要成果:
- 在52个LuTR中,20%发生了细胞巨核病毒 (CMV) 感染,往往对预防有抗性.
- 与埃普斯坦-巴尔病毒 (EBV) 相关的移植后淋巴增殖性疾病 (PTLD) 在6%的患者中发生.
- 细菌 (48%) 和侵入性真菌 (10%) 感染也很常见;脱敏和维持组之间的发病率相似.
结论:
- 在LuTRs治疗贝拉塔塞普的第一年与CMV,EBV+ PTLD和细菌感染的高发病率有关.
- 多中心研究对于全面了解肺移植中贝拉塔塞普相关的感染风险至关重要.
相关概念视频
01:29Pulmonary Tuberculosis I
220
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
220
01:25Transmission-based Precautions II: Airborne and Protective Environment
1.2K
Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
1.2K