患有神经性膀的儿童的增强细胞塑造:经过30年的经验后的长期结果
Carlos Delgado-Miguel1,2, Virginia Amesty3, Susana Rivas3
1Department of Pediatric Urology, La Paz Children's University Hospital, Madrid, Spain - carlosdelgado84@hotmail.com.
Minerva urology and nephrology
|November 4, 2024
概括
增强细胞形成术 (AC) 为神经性膀提供了有效的长期治疗,显著增加了膀容量. 由于潜在的晚期并发症,密切的临床随访至关重要.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 手术创新 在外科创新.
- 儿科泌尿外科 儿科泌尿外科
背景情况:
- 增强细胞形成术 (AC) 是神经病性膀的外科选择.
- 对AC的长期结果没有得到充分的证据.
- 这项研究评估了30年的交流经验.
研究的目的:
- 评估增强细胞形成术的长期疗效和安全性.
- 分析AC治疗的神经病性膀患者的结局和并发症.
- 评估AC对膀容量和相关疾病的影响.
主要方法:
- 追溯研究86名患有神经病的膀患者接受了AC (1990-2020年).
- 收集的数据包括人口统计,尿动力学,结果和并发症.
- 手术技术涉及大肠,西格玛或尿管进行增强;一些患者接受了人工尿 (AUS).
主要成果:
- 手术后AC显著增加了膀容量,从手术后的平均117毫升升至430毫升 (P<0.001).
- 在78.9%的患者中,膀-尿道逆流改善.
- 长期随访 (中位数为24.5年) 显示出并发症,包括AUS问题 (7例) 和膀结石病 (9例患者);膀癌的一例发生在AC后16年.
结论:
- 增强细胞塑性是一种有效的长期治疗神经病性膀不响应医疗治疗.
- 患者需要终身监测潜在的晚发症并发症.
- AC显示了持续的功能改善和相关泌尿器科问题的管理.
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