相关实验视频

Updated: Jun 8, 2025

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells

Published on: September 18, 2016

在肠道炎症期间,肠道质细胞对抗原呈现的功能分析

Ryan M Brown^1,2,3, Helen H Le^1,2, Isaac W Babcock^1,2,3

¹Center for Brain Immunology and Glia, University of Virginia School of Medicine, Charlottesville, Virginia, USA.

|November 4, 2024

概括

肠质细胞通过MHC I呈现抗原,包括交叉呈现,但不是MHC II. 这些细胞在感染期间对MHC I进行上调,这表明它们在CD8+ T细胞反应中起作用.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
胃肠病学胃肠病学

背景情况:

肠道质细胞 (EGC) 对肠道平衡和免疫调节至关重要.
通过MHC II,EGCs已被提出为抗原呈现细胞 (APC),但这在功能上仍未得到证实.
了解EGC抗原呈现是破译肠道免疫反应的关键.

研究的目的:

调查EGCs在MHC I和MHC II上的抗原表现的功能能力.
在实验性肠道炎症期间确定EGC MHC I和MHC II表达水平.
阐明EGCs在调节肠道T细胞反应中的作用.

主要方法:

在体外抗原呈现测试使用初级小鼠EGC培养物.
对EGC细胞表面MHC I和MHC II表达的流细胞计分析.
在小鼠实验性结肠炎 (DSS) 和感染 (T. gondii) 模型的诱导.

主要成果:

EGCs在MHC I上显示了功能性抗原呈现,包括交叉呈现.
EGCs无法在MHC II上呈现功能性抗原.
在T. gondii感染期间,EGC上调了MHC I,并在炎症期间显示了低水平的MHC II诱导.

结论:

EGCs能够进行MHC I介导的抗原呈现,可能调节CD8+ T细胞的反应.
EGC不太可能参与MHC II介导的抗原呈现.
EGC在通过MHC I呈现来调节肠道免疫力方面发挥着重要作用.

关键词:

抗原呈现的呈现方式.肠道的质细胞.炎症性肠病是一种炎症性肠病.肠道炎症是一种肠道炎症.毒性质淋巴细胞 (Toxoplasma gondii) 的发生

更多相关视频

Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse

Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse

Published on: August 15, 2018

Author Spotlight: Isolation and Characterization of Equine Submucosal Enteric Glia — Implications for Preventing Postoperative Complications in Colic Surgery

Author Spotlight: Isolation and Characterization of Equine Submucosal Enteric Glia — Implications for Preventing Postoperative Complications in Colic Surgery

Published on: October 4, 2024

相关概念视频

Antigen Presenting Cells

Antigen Presenting Cells

The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...

Antigen Processing Pathways

Antigen Processing Pathways

MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...