美国国立卫生研究院治疗疼痛常见数据元素 (CDE):一个很好的开始,但到达终点线的路很长
Meredith C B Adams1,2,3,4,5, Afton L Hassett6, Daniel J Clauw6,7,8,9
1Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, United States.
Pain medicine (Malden, Mass.)
|November 4, 2024
概括
国家卫生研究院 (NIH) 疼痛常见数据元素 (CDE) 提供了一个标准化的疼痛研究框架. 解决实施挑战对于一致,有效的疼痛数据至关重要,以推进研究和患者护理.
科学领域:
- 疼痛研究方法的方法论.
- 临床试验数据标准化标准化
- 生物医学信息学是生物医学信息学.
背景情况:
- 国家卫生研究院 (NIH) 疼痛常见数据元素 (CDE) 旨在标准化疼痛研究.
- 这些CDE的实施和解释存在挑战.
- 标准化对于一致和可比的疼痛研究数据至关重要.
研究的目的:
- 审查NIH CDE计划的疼痛领域.
- 在临床试验和二次数据分析中提供CDE实施的最佳实践.
- 为适当的CDE使用提供一个检查清单.
主要方法:
- 对10个NIH核心疼痛研究领域的分析.
- 讨论CDE使用的限制和考虑.
- 开发实施场景和指导检查清单.
主要成果:
- 10个核心疼痛领域的概述:强度,干扰,功能,睡眠,灾难化,抑郁,焦虑,改变的总体印象,物质使用和生活质量.
- 提供了示例场景,用于执行要求的问题.
- 提出了一个检查清单,以指导研究人员有效利用疼痛CDE.
结论:
- 确定的挑战包括上下文的变化,缺乏验证,以及对措施的潜在滥用.
- 提出的解决方案包括补充措施,特定背景的指导,培训和框架的完善.
- 解决实施和解释方面的挑战是推动疼痛研究和患者护理的关键.
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