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Anatomy of the Eyeball01:20

Anatomy of the Eyeball

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The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
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Updated: Jun 8, 2025

Using Retinal Imaging to Study Dementia
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在晚期多发性硬化症中视网膜功能.

James V M Hanson1, Sara Single1, Rahel B Eberle2

  • 1Department of Ophthalmology, University Hospital Zurich and University of Zurich, Zurich, Switzerland.

Investigative ophthalmology & visual science
|November 4, 2024
PubMed
概括
此摘要是机器生成的。

电网膜学 (ERG) 在多发性硬化症 (MS) 患者中显示出异常的视网膜双极细胞功能,这些患者具有中度至重度的残疾. 然而,ERG与早期的疾病发现并没有区别,对于MS监测或预后不太可能有用.

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科学领域:

  • 神经科学是一个神经科学.
  • 眼科医生 眼科 眼科
  • 神经学 神经学

背景情况:

  • 多发性硬化症 (MS) 涉及神经退行,需要可靠的功能标志物.
  • 之前的研究表明,在早期多发性硬化症,特别是双极性细胞功能障碍中,有电网膜学 (ERG) 变化.
  • 在先进的MS中ERG的实用性需要进一步研究.

研究的目的:

  • 调查电网光学 (ERG) 作为多发性硬化症 (pwMS) 和中度至重度残疾 (EDSS ≥3.0) 患者的潜在结果测量方法.
  • 为了比较pwMS中的ERG发现,有和没有视神经炎 (ON) 史与健康对照 (HC).
  • 评估扩展残疾状况尺度 (EDSS),疾病持续时间,ON和治疗对ERG结果的影响.

主要方法:

  • 横截面观察性研究比较pwMS (EDSS ≥3.0) 和HC参与者.
  • 使用了ERG,光学连贯性断层扫描,视敏测试和眼科检查.
  • 分析ERG参数,包括适应黑暗的3.0b波和适应光的闪,与临床和疾病特征相关.

主要成果:

  • 在MS眼睛中观察到适应黑暗的3.0b波和适应光的闪ERG的延迟峰值时间,而不管ON史.
  • 在ERG异常与EDSS得分,疾病持续时间,ON病史或治疗状态之间没有发现显著的相关性.
  • 探索性分析显示,MS表型或疾病活性对ERG发现没有明显的影响.

结论:

  • 在pwMS中,ERG揭示了视网膜双极细胞功能的异常,具有中度至重度残疾.
  • 这些ERG发现与MS早期阶段的ERG结果一致.
  • 因此,ERG不太可能成为监测疾病进展或在MS中预后的有价值工具.