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Updated: Jun 8, 2025

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ACE2通过抑制巨细胞诱导的免疫抑制和血管生成来提高对PD-L1阻塞的敏感性

Peiyi Xie1, Lei Guo1, Qiang Yu1

  • 1Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, P.R. China.

Cancer research
|November 4, 2024
PubMed
概括

ангиотензин转化酶2 (ACE2) 缺乏促进肝细胞癌 (HCC) 通过增加免疫抑制性M2巨细胞通过增加抗PD-L1免疫治疗的耐药性. 恢复ACE2功能可能会改善HCC治疗结果.

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