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Updated: Jun 8, 2025

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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通过MAPK诱导PHGDH对黑色素瘤形成至关重要,并产生可操作的代谢脆弱性

Neel Jasani1,2, Xiaonan Xu1, Benjamin Posorske1

  • 1Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.

Cancer research
|November 4, 2024
PubMed
概括

糖酸脱酶 (PHGDH) 驱动黑色素瘤的生长. 通过抑制BRAFV600E和限制血清蛋白来向PHGDH,为黑色素瘤提供了一种特定的治疗策略.

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