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增强面部或面部疼痛缓解:α-phellandrene复合与基烯-β-cyclodextrin缓解面部或面部痛感在动物

Brennda Gonzaga Machado¹, Fabíolla Rocha Santos Passos¹, Ângelo Roberto Antoniolli¹

¹Department of Physiology, Federal University of Sergipe (UFS), São Cristóvão, SE, Brazil.

Naunyn-Schmiedeberg's archives of pharmacology

|November 4, 2024

概括

一项新的研究表明,阿尔法-费兰德 (PHE) 与基-β-环氧德 (PHE-HPβCD) 复合有效地减少了面部或面部疼痛. 这种有前途的治疗可以缓解疼痛和炎症,为新的口腔面部疼痛疗法提供了潜力.

科学领域:

药理学药理学是指药理学的学科.
疼痛管理疼痛管理
自然产品自然产品

背景情况:

面部或口腔疼痛影响10-15%的成年人,这给治疗带来了重大挑战.
阿尔法-费兰德烯 (PHE) 是一种单烯,在缓解疼痛方面显示出潜在的治疗益处.
开发有效的输送系统对于提高PHE的治疗疗效至关重要.

研究的目的:

开发和表征一个包含的复杂的α-phellandrene (PHE) 与xypropyl-β-cyclodextrin (PHE-HPβCD).
为了评估PHE-HPβCD在临床前的口腔面部疼痛模型中的疗效.
调查PHE-HPβCD对 orofacial疼痛中的炎症媒介的影响.

主要方法:

通过物理混合制备的PHE-HPβCD纳入复合物.
使用差分扫描热量计 (DSC) 和高性能液体染色学 (HPLC) 进行表征.
评估小鼠的口面疼痛模型 (甲素,甲,谷氨酸,高血压盐水) 并测量TNF-α和IL-1β水平.

主要成果:

该PHE-HPβCD复合体实现了70.45%的封装效率.
无论是PHE还是PHE-HPβCD,都在甲素诱导的口腔面部疼痛中表现出显著的抗受体效应.
PHE-HPβCD显著降低了促炎性细胞因子TNF-α和IL-1β,并改善了角膜 nociception.

结论:

PHE,特别是在PHE-HPβCD复合体中,通过调节疼痛通路和减少炎症,有效地缓解口腔疼痛.
该复合物显示出治疗各种口腔面部疼痛疾病的潜力,包括涉及TRPA1/TRPV1受体和谷氨酸酸的疾病.
PHE-HPβCD代表了一种有前途的治疗策略来控制面部疼痛,需要在慢性疼痛模型中进一步调查.

关键词:

循环德克斯特林 (Cyclodextrin) 是一种循环德克斯特林.单烯是一种单烯.面部或面部疼痛面部疼痛 α-phellandrene 是一个类型.

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