在2023年中期,匈牙利西南部发生与18型 (E18) 声波病毒相关的脑膜炎疫情
Károly Takáts1, Benigna Balázs1, Ákos Boros1
1Department of Medical Microbiology and Immunology, Medical School, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.
Archives of virology
|November 4, 2024
概括
一个不寻常的埃科病毒18型 (E18) 爆发导致匈牙利成年人脑膜炎. 该研究在脑脊液中发现了E18和详细的常见症状,强调需要对新出现的变种进行持续监测.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 神经学 神经学
背景情况:
- 埃科病毒18型 (E18) 是皮科纳病毒家族中的一种肠道病毒.
- 脑膜大脑炎是一种严重的神经疾病,影响大脑及其周围的膜.
- 肠道病毒感染可能会引起严重的公共卫生问题,特别是在疫情爆发期间.
研究的目的:
- 在患有脑膜炎的住院成年人中特征化埃科病毒18型 (E18) 感染.
- 调查2023年中期在匈牙利西南部发生的一次不寻常的E18流行病.
- 分析循环中的E18菌株的遗传关系.
主要方法:
- 从住院患者的脑脊髓液 (CSF) 样本中检测了肠道病毒的存在.
- 通过分子方法确定了E18的阳性样本.
- 对已识别的E18菌株进行了序列分析.
- 收集和分析了包括症状在内的临床数据.
主要成果:
- 在82个脊髓样本中,在5个 (6.1%) 检测到肠道病毒.
- 检测到的四种肠道病毒被确定为18型埃科病毒 (E18).
- 常见的症状包括头痛,发烧,后巴疼痛,恶心和关节/四肢疼痛.
- 序列分析显示与来自法国和中国的新兴E18菌株有关.
结论:
- 埃科病毒18型 (E18) 在2023年匈牙利疫情期间被确定为脑膜炎的原因.
- 已识别的E18菌株显示与最近的国际分离物有遗传联系.
- 持续监测流行病和流行病E18变种至关重要.
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