长期COVID患者中线粒体功能障碍的新生物标志物
Titanilla Szögi1, Barbara N Borsos1,2, Dejana Masic1
1Department of Pathology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
GeroScience
|November 4, 2024
概括
长期COVID患者表现出显著的线粒体结构异常和氧化应激,表明严重的细胞能量代谢中断. 减少循环无细胞线粒体DNA (ccf-mtDNA) 水平为这种后病毒性疾病提供了一个新的生物标志物.
科学领域:
- 细胞生物学 细胞生物学
- 病理生理学 病理生理学
- 生物标志物发现发现
背景情况:
- 持续的症状,称为长期COVID或PASC,影响30-40%的SARS-CoV-2感染后的个人.
- 长期COVID症状包括疲劳,呼吸系统问题,认知缺陷和睡眠障碍,持续数月.
- 最近的研究将SARS-CoV-2感染与长期的线粒体功能障碍和改变的细胞能量代谢联系起来.
研究的目的:
- 为了研究长期COVID患者的线粒体结构异常.
- 为了识别与长期COVID病变发生相关的新生物标志物.
- 探索线粒体功能障碍在长期COVID中的作用.
主要方法:
- 传输电子显微镜 (TEM) 用于可视化线粒体形态.
- 测量超氧化物脱酶1 (SOD1) 和与自相关的4B (ATG4B) 水平.
- 循环的无细胞线粒体DNA (ccf-mtDNA) 的量化.
主要成果:
- 在长期COVID患者中,TEM揭示了显著的线粒体胀,受损的晶状体和不规则的形态.
- 增加的SOD1水平表明氧化应激增加.
- 升高的ATG4B表明线粒细胞断,并且降低ccf-mtDNA水平被确定为一种新的生物标志物.
结论:
- 持续的线粒体功能障碍在长期COVID的发病过程中至关重要.
- ccf-mtDNA和其他线粒体生物标志物可以提高长期COVID的诊断和管理.
- 对病毒后线粒体功能障碍机制的进一步研究对于向治疗至关重要.
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