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Updated: Jun 8, 2025

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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在膀癌中TGF-β表达的预后价值:系统性审查和元分析

Shima Kianmehr1, Mohammad Vahabirad1, Atefeh Seghatoleslam2

  • 1Department of Clinical Biochemistry, Hamadan University of Medical Sciences School of Medicine, Hamadan, Iran.

Urology research & practice
|November 4, 2024
PubMed
概括

转化生长因子β (TGF-β) 表达表明膀癌患者的预后更差. 这一元分析证实TGF-β是膀癌进展的显著预后标志物.

关键词:
膀癌是一种癌症.在TGF-β的基础上.进行元分析分析.预后 预后 预后

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The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
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