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患者的真实世界结局胸膜间皮瘤:一个多站点的回顾性队列研究

Kar Ven Cavan Chow^1,2, Cassie Turner^1,2,3, Brett Hughes^2,3,4

¹The Adem Crosby Cancer Centre, Department of Medical Oncology, Sunshine Coast Hospital and Health Service, Sunshine Coast, Australia.

Asia-Pacific journal of clinical oncology

|November 4, 2024

概括

这项研究评估了现实世界的肺部间皮瘤 (PM) 治疗方法. 化疗和免疫疗法都显示出活性,但患者的预后仍然很差,这凸显了需要改进治疗的需要.

科学领域:

在瘤学瘤学.
胸部医学胸部医学
临床研究临床研究

背景情况:

胸腔半质瘤 (PM) 是一个重大的治疗挑战.
免疫治疗的出现改变了各种癌症的治疗模式.
现实世界的数据对于了解PM的治疗模式和结果至关重要.

研究的目的:

评估为肺部间皮瘤患者的现实世界治疗策略.
在新兴免疫疗法背景下评估治疗结果.
确定PM的第一线和后续疗法需要改进的领域.

主要方法:

在澳大利亚三所高等推中心对90名肺部间皮瘤患者进行了回顾性审计 (2017年1月 - 2023年7月).
收集和分析患者的人口统计数据,治疗特征和临床结果.
使用了描述性统计和卡普兰-梅尔生存分析.

主要成果:

第一线治疗包括化疗 (63%) 或最佳支持性护理 (BSC, 37%). 在2021年7月的补偿后,免疫疗法使用量增加.
只有40%接受了二线治疗;60%接受了BSC.
所有患者的12个月整体存活率为53%,免疫疗法为72%,化疗为64%,BSC为29%. 化疗和免疫治疗之间没有显著的生存差异 (p=0.5).

结论:

化疗和免疫疗法在现实世界肺间皮质瘤队列中表现出活性.
对于PM患者的预后仍然保持谨慎,强调需要新的治疗选择.
临床试验招生对于推进PM患者的治疗结果至关重要.

关键词:

澳大利亚澳大利亚澳大利亚免疫疗法免疫疗法胸腔间皮瘤 (PLEURAL MESOTHELIOMA) 是一种多发性中皮瘤.现实世界的世界.

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