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Updated: Jun 8, 2025

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes
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在人类胎儿大脑皮层中亚板神经元的分子血统和空间分布

Xueyu Guo1, Trevor Lee2, Jason Sun3

  • 1Center for Precision Medicine, Huaqiao University, Xiamen, Fujian, 361021, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|November 4, 2024
PubMed
概括

亚板神经元 (SPN) 对人类大脑发育至关重要. 这项研究绘制了它们在胎儿大脑中的起源和分子途径的地图,揭示了它们在神经发生和皮层折叠中的作用.

关键词:
大脑皮层 大脑皮层人类胎儿大脑人类胎儿大脑一个单细胞RNA测序.空间转录学 空间转录学亚板神经元的神经元

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Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
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