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Updated: Jun 8, 2025

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通过巨分子拥挤和错误折叠的蛋白质直接激活HSF1

Oliver Simoncik1,2, Vlastimil Tichy1, Michal Durech1

  • 1Research Centre for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Brno, Czech Republic.

PloS one
|November 4, 2024
PubMed
概括

热冲击因子蛋白1 (HSF1) 作为分子拥挤传感器,三元化启动细胞保护反应. 这种激活增强了伴侣活动以恢复平衡,即使与Hsp70和Hsp90.0结合.

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