稳定精神分裂症患者在医院环境中的营养指标和认知功能之间的相关性
Binyou Wang1, Yong Zhou1, Han Yu1
1Department of Psychiatry, Zigong Mental Health Center, The Zigong Affiliated Hospital of Southwest Medical University, Zigong, Sichuan Province, China.
PloS one
|November 4, 2024
概括
这项研究发现,精神分裂症患者的预后营养指数 (PNI) 和认知功能之间存在显著联系. 在MoCA-C测试中,较高的PNI分数与更好的认知表现相关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 营养科学 营养科学
背景情况:
- 认知障碍是精神分裂症的一个关键特征.
- 营养状况越来越被认为是影响精神疾病认知功能的因素.
研究的目的:
- 调查三个营养指标 (PNI,GNRI,CONUT) 与稳定精神分裂症住院患者的认知功能之间的相关性.
- 评估预后营养指数 (PNI),老年营养风险指数 (GNRI) 和控制营养状况 (CONUT) 评分和认知表现之间的关系.
主要方法:
- 分析了235名患有稳定精神分裂症的住院患者.
- 用中国蒙特利尔认知评估 (MoCA-C) 评估认知功能.
- 预后营养指数 (PNI),老年营养风险指数 (GNRI) 和控制营养状况 (CONUT) 评分是使用血清白蛋白,总胆固醇,淋巴细胞计数和BMI计算的.
主要成果:
- 在预后营养指数 (PNI) 和MoCA-C得分 (r = 0.15,P = 0.021) 之间发现了显著的正相关性.
- 这种关联通过对共变量调整的线性和有序后勤回归模型得到证实.
- 在GNRI或CONUT得分和认知功能之间没有发现显著的相关性.
结论:
- 预后营养指数 (PNI) 与稳定的精神分裂症住院患者的认知功能有显著的关联.
- 在这种人群中,PNI可以作为评估认知状态的有用营养指标.
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