巴西帕金森病患者患有抑郁症状,接受下体内核深度大脑刺激治疗:一个横截面研究
Thayná Laís de Souza Arten1, Amer Cavalheiro Hamdan1
1Department of Postgraduate Studies in Psychology, Universidade Federal do Paraná (UFPR), Curitiba, Brazil.
Applied neuropsychology. Adult
|November 4, 2024
概括
对帕金森病 (PD) 的深度大脑刺激 (DBS) 可能会使认知功能恶化,并增加某些患者的抑郁症状. 针对性护理对于在接受DBS治疗的PD患者中管理这些复杂效应至关重要.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 帕金森病 (PD) 是一种神经退行性疾病,影响运动控制,经常与抑郁症同时发生.
- 脑下核深度大脑刺激 (STN-DBS) 是PD的治疗选择,但它对情绪和认知的影响尚未完全理解.
- 了解PD,STN-DBS和心理健康之间的相互作用对于优化患者的治疗结果至关重要.
研究的目的:
- 为了研究帕金森病,STN-DBS和巴西患者抑郁症状之间的关系.
- 评估STN-DBS对认知功能和情绪的影响.
- 确定与STN-DBS在PD中的结果相关的因素.
主要方法:
- 研究了两个帕金森病患者队列 (2019年:n=46;2022年:n=31).
- 使用老年抑郁量表-15和贝克抑郁量表-II评估抑郁症状.
- 评估了认知表现和日常生活活动 (ADL),将STN-DBS患者与仅用药治疗的患者进行比较.
主要成果:
- 没有发现与STN-DBS存在的性别相关性.
- 在患者组之间观察到年龄,疾病持续时间和ADL得分的显著差异.
- 与药物治疗患者相比,STN-DBS患者在一个队列中表现出较差的认知表现和更高的抑郁症得分.
结论:
- 帕金森病中的STN-DBS与认知功能和抑郁症状存在复杂的关系.
- 这些发现表明STN-DBS可能会对某些PD患者的认知和情绪产生负面影响.
- 个性化治疗策略是必要的,以解决STN-DBS在帕金森病管理中的多方面的影响.
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