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小儿急性淋巴细胞白血病中的淋巴细胞子集及其预后价值

Luyun Peng^1,2, Qingkai Dai^1,2, Yuefang Wang^1,2

¹Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.

|November 4, 2024

概括

与健康儿童相比,儿童急性淋巴细胞白血病 (ALL) 在诊断时显示出明显的淋巴细胞子集变化. CD4+ T 细胞水平是儿童ALL临床结果的关键预测因素.

科学领域:

免疫学免疫学免疫学
儿科瘤学儿科瘤学
流动细胞计量 (Flow Cytometry) 是一种流动细胞计.

背景情况:

急性淋巴细胞白血病 (ALL) 是一种常见的儿童癌症.
在各种免疫条件下观察到淋巴细胞子集的改变.
了解ALL的免疫细胞动态对于预后至关重要.

研究的目的:

在诊断时调查儿科ALL的淋巴细胞子集变化.
将这些子集与健康儿童和完全缓解 (CR) 的儿童进行比较.
为了确定淋巴细胞子集在儿科ALL的预后意义.

主要方法:

405名在诊断时患有ALL的儿童的外周血液的流细胞计分析.
在ALL患者,健康对照患者和CR患者之间对淋巴细胞子集百分比的比较.
生存和预后因素分析,包括多变量分析.

主要成果:

与健康儿童和CR患者相比,在儿科ALL中发现了淋巴细胞子集的显著差异.
淋巴细胞子集与最小残留疾病和风险参数相关.
CD3+ T 细胞,CD4+ T 细胞的百分比和CD4/CD8比率与临床结果有关.

结论:

淋巴细胞子集在儿科ALL中经历了显著的变化.
CD4+ T细胞百分比是儿科ALL临床预后的独立预测指标.
淋巴细胞子集分析为儿童ALL提供了有价值的预后信息.

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