日间小睡和与代谢相关的脂肪肝疾病:观察性研究的系统审查和元分析
Linxiao Gao1, Jianping Gong, Guochao Zhong
1Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, P.R. China.
Medicine
|November 4, 2024
概括
午睡与非酒精性脂肪性肝病 (NAFLD) 和代谢相关脂肪性肝病 (MAFLD) 的更高发病率有关. 长时间的午睡显著增加了风险,而短暂的午睡没有显著影响.
科学领域:
- 代谢健康 代谢健康
- 肝病学 肝病学是一种肝病学.
- 睡眠科学 睡眠科学
背景情况:
- 午睡对健康的影响很大,人们对它与代谢疾病的联系越来越感兴趣.
- 关于午睡和非酒精性脂肪性肝病 (NAFLD) /代谢相关脂肪性肝病 (MAFLD) 的以前的研究产生了有争议的结果.
研究的目的:
- 系统地分析小睡和NAFLD/MAFLD发病率之间的关联.
- 调查午睡时间对NAFLD/MAFLD风险的影响.
主要方法:
- 进行了系统的文献搜索,截至2024年7月31日.
- 使用固定效应模型计算聚合赔率比率 (ORs).
- 敏感性分析,元回归,漏斗图和埃格尔测试被用于评估异质性和出版偏差.
主要成果:
- 分析包括13项研究,共有48,248名参与者.
- 午睡与NAFLD/MAFLD发病率的增加有关 (OR,1.13;P < .001).
- 长时间的午睡时间与更高的疾病风险有显著联系 (OR,1.21;P = .03),而短时间的午睡没有显著影响发病率 (OR,1.01;P = .80).
结论:
- 在NAFLD/MAFLD患者中,午睡的习惯可能更为普遍.
- 需要进一步的研究来探索剂量-反应关系,混因素和因果关系.
- 该研究协议已注册在PROSPERO (CRD42023439507) 公司.
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