甲状腺功能和对甲状腺激素的敏感性与脊髓骨矿物质含量,骨矿物质密度和骨质疏松性脊椎骨折的相关性:基于NHANESES的横截面研究
Qilin Wang1, Yueran Wang, Yuhao Jia
1Department of Orthopaedics, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Medicine
|November 4, 2024
概括
甲状腺功能影响骨健康,较高的甲状腺激素水平 (FT3/FT4) 与较低的骨矿物质含量 (BMC) 和高甲状腺过氧化酶抗体 (TPOAb) 相关,与骨质疏松性脊椎骨折 (OVF) 风险增加有关.
科学领域:
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
- 公共卫生 公共卫生
背景情况:
- 甲状腺激素对骨发育和质量至关重要.
- 甲状腺状况与骨矿物质密度 (BMD),骨矿物质含量 (BMC) 和骨质疏松性脊椎骨折 (OVF) 之间的关系需要进一步调查.
- 了解甲状腺功能 (TF) 和甲状腺激素敏感性是骨健康的关键.
研究的目的:
- 调查甲状腺状况 (包括甲状腺功能和激素敏感性) 与脊椎BMC,BMD和OVF之间的关联.
- 分析来自国家健康和营养检查调查 (NHANES) 数据库的数据.
主要方法:
- 从NHANES数据库中对1844名参与者的分析.
- 使用的甲状腺功能指数和甲状腺激素敏感度指数.
- 采用单变量和多变量加权回归模型,受限立方线和子组分析.
主要成果:
- 较高的自由三甲状腺素 (FT3) /自由甲状腺素 (FT4) 水平与脊柱 BMC 有负面关联.
- 甲状腺过氧化酶抗体 (TPOAb) 水平升高显著与OVF风险增加有关.
- 限制性立方线模型证实了多变量回归分析的发现.
结论:
- 增加FT3/FT4和TPOAb与脊柱BMC减少和OVF风险增加有关.
- 甲状腺状况与骨健康有着复杂的关系,特别是在脊椎骨.
- 患有甲状腺疾病或TPOAb/FT3/FT4升高的个体应优先预防骨质疏松症,骨质疏松症和OVF.
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