幸存于COVID-19的患者在Omicron时代与早期时代相比,长期COVID的风险较低
1University of Texas at Austin Dell Medical School, Austin, Texas, USA (S.S.).
Annals of internal medicine
|November 4, 2024
概括
长期COVID风险在SARS-CoV-2变种之间有所不同. 在奥米克朗时代,一些后COVID疾病的风险降低了,但其他疾病的风险增加了,包括心血管问题.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- SARS-CoV-2 变种的出现 (德尔塔前,德尔塔,奥米克朗) 改变了COVID-19 的格局.
- 了解与SARS-CoV-2感染相关的长期健康后果或后急性后果对于公共卫生至关重要.
- 之前的研究表明,长期COVID的风险因感染变异而有所不同.
研究的目的:
- 为了比较SARS-CoV-2感染的急性后续病例的发病率和类型,通过主要变种定义的不同时代进行比较:前-Delta,Delta和Omicron.
- 为了确定可能在不同SARS-CoV-2变种感染后的后急性阶段或多或少地流行的特定健康状况.
主要方法:
- 使用大规模健康数据库进行回顾性队列研究.
- 包括在Delta,Delta和Omicron变体前时代感染SARS-CoV-2的个人.
- 分析了广泛的后急性后果的发病率,并比较了不同变异时代之间的结果.
主要成果:
- 发生某些SARS-CoV-2感染后急性后果的风险在Delta前,Delta和Omicron时代有显著差异.
- 虽然与之前的时代相比,Omicron时代的总体风险较低,但它显示了特定疾病的风险增加,特别是心血管疾病.
- 特定的器官系统和条件显示出与每个变体相关的不同风险模式.
结论:
- 在SARS-CoV-2感染后的急性后续症状的特征是动态的,并受到主导病毒变种的影响.
- 虽然Omicron变种在某些方面可能不那么严重,但对长期健康,特别是心血管并发症带来了明显而显著的风险.
- 这些发现强调需要持续监测和量身定制的公共卫生战略,以管理SARS-CoV-2感染的各种长期后果.
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