杆菌感染与非酒精性脂肪性肝病无关:为期两年的队列研究
Huabo Zheng1,2, Tangmeng Guo1, Xiaofang Zhao1
1Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Digestive diseases (Basel, Switzerland)
|November 4, 2024
概括
在一项大型队列研究中,Helicobacter pylori感染与非酒精性脂肪性肝病 (NAFLD) 的发展没有显著关联. 其他因素,如BMI和血脂被确定为NAFLD的关键风险或保护因素.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
背景情况:
- 之前关于Helicobacter pylori (H. pylori) 感染和非酒精性脂肪肝疾病 (NAFLD) 之间的联系的研究已经产生了不一致的结果.
- 澄清这种关联对于理解NAFLD病原体至关重要.
研究的目的:
- 调查H. pylori感染与NAFLD发展之间的潜在关联.
- 在一大批成年人中确定NAFLD发展的风险和保护因素.
主要方法:
- 一项队列研究,涉及2063名在基线没有NAFLD的成年人.
- 使用13C尿素呼吸试验检测H.pylori和腹部超声波检测NAFLD评估.
- 随访参与者的平均时间为1.7年.
主要成果:
- 在H. pylori感染和NAFLD发展之间没有发现显著的关联 (HR = 1.10,p = 0.4689).
- 鉴定了NAFLD的风险因素:年龄较大,BMI较高,血压升高,禁食葡萄糖,甘油三,总胆固醇,LDL-C,ALT和AST.
- 高密度脂蛋白胆固醇 (HDL-C) 已成为抗NAFLD的保护因素.
结论:
- 杆菌感染似乎不是NAFLD发展的显著积极风险因素.
- 已确定的代谢因素在NAFLD病变发生过程中仍然至关重要.
相关概念视频
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
89
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
89
01:16Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
328
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
328
01:30Peptic Ulcer Disease I: Introduction
139
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
139
01:17Gastritis-II: Pathophysiology
261
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
261
01:23Gastritis III: Clinical Manifestations and Management
161
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
161
01:22Pathophysiology of Peptic Ulcer Disease: Injurious Factors
542
Peptic ulcers are sores on the stomach's inner lining and the upper small intestine, which are the result of disruptions in the mucosal layer that houses parietal cells which produce gastric acid, and chief cells which secrete pepsinogen.
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
542