患有阿片类药物使用障碍的患者选择使用延长释放纳尔德治疗:一项为期6个月的自然主义研究
Ida Halvorsen Brenna1,2, Karin Merethe Waleur3,4, Jūratė Šaltytė Benth5,6
1Department of Addiction Medicine, Haukeland University Hospital, Bergen, Norway.
European addiction research
|November 4, 2024
概括
延长释放纳尔德 (XR-NTX) 在自然环境中显示出高保留率和减少阿片类药物使用. 完成24周的XR-NTX治疗导致了阿片类药物使用障碍 (OUD) 的更好的结果.
科学领域:
- 药物中毒药物 药物中毒药物
- 药理学 药理学是指药理学的学科.
- 临床研究是临床研究.
背景情况:
- 延长释放纳勒 (XR-NTX) 对阿片类药物使用障碍 (OUD) 的疗效已确立,但在可获得阿片类药物激动剂治疗 (OAT) 的环境中,现实世界的数据有限.
- 这项研究评估了XR-NTX结果,当参与者自愿选择它而不是OAT时.
研究的目的:
- 为了评估XR-NTX在自然的门诊环境中的有效性.
- 为了检查与OUD的XR-NTX相关的治疗保留,物质使用,渴望,满意度和不良事件.
主要方法:
- 一项为期24周的开放标签前性队列研究,涉及挪威161名OUD成年参与者.
- 参与者每4周内接受肌肉内XR-NTX注射.
- 测量结果包括治疗延续,阿片类药物/物质使用,渴望,满意度和不良事件.
主要成果:
- 高保留率:60.9%的参与者完成了24周的XR-NTX治疗.
- 阿片类药物和酒精使用的显著减少 (p < 0.001);其他非法物质的使用很低.
- 参与者报告高治疗满意度和低海洛因渴望;完成与更好的结果相关.
结论:
- 在自然主义的OUD治疗环境中,XR-NTX显示了高保留率和减少了阿片类药物/酒精的使用.
- 完成完整的24周治疗疗程与早期停止相比,显著改善了治疗结果.
- 参与者对戒断的动机可能有助于观察到的高保留率和减少使用.
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