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通过对复杂结构的定量动态分析,了解和预测μ-阿片类受体中的配体效率

Gabriel T Galdino1, Olivier Mailhot1, Rafael Najmanovich2

  • 1Department of Pharmacology and Physiology Faculty of Medicine, University of Montreal, 2960 Chemin de la Tour, H3T 1J4 Montréal, Quebec, Canada.

Journal of chemical information and modeling
|November 4, 2024
PubMed
概括

这项研究通过分析受体动态来预测药物分子如何激活μ-阿片类受体 (MOR). 定量动力学活动关系 (QDAR) DynaSig-ML方法准确预测药物的疗效,有助于新的止痛药开发.

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