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Updated: Jun 8, 2025

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis
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A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis

Published on: May 22, 2018

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[发现了JAL-TA9,它通过蛋白质分解活性将粉样β分裂]

Rina Nakamura1,2

  • 1Department of Pharmacology, Kochi Medical School, Kochi University.

Nihon yakurigaku zasshi. Folia pharmacologica Japonica
|November 4, 2024
PubMed
概括

在阿尔茨海默氏病模型中,一种新型合成,JAL-TA9,显示出蛋白酶活性,在阿尔茨海默氏病模型中分裂有毒的粉样β 42 (Aβ42). 这一发现为开发基于的阿尔茨海默氏症疗法提供了新的途径.

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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