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[JAL-TA9对阿尔茨海默病模型小鼠认知缺陷的影响]

Suo Zou1,2

  • 1Department of Pharmacology, Kochi Medical School, Kochi University.

Nihon yakurigaku zasshi. Folia pharmacologica Japonica
|November 4, 2024
PubMed
概括

一种新,JAL-TA9,有效清除粉样β斑块,并改善阿尔茨海默病 (AD) 模型的记忆力. 通过鼻子给药显示出治疗甚至晚期AD痴呆症的前景.

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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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