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Updated: Jun 8, 2025

Monitoring Leucine-Rich Repeat Containing 8 Channel (LRRC8/VRAC) Activity Using Sensitized-Emission Förster Resonance Energy Transfer (SE-FRET)
08:54

Monitoring Leucine-Rich Repeat Containing 8 Channel (LRRC8/VRAC) Activity Using Sensitized-Emission Förster Resonance Energy Transfer (SE-FRET)

Published on: August 9, 2024

388

斯芬戈辛-1-酸盐通过Gβγ信号传递激活LRRC8体积调节的离子通道

Yulia Kostritskaia1, Sumaira Pervaiz2, Anna Klemmer1

  • 1Institute for Molecular Medicine, MSH Medical School Hamburg, Hamburg, Germany.

The Journal of physiology
|November 4, 2024
PubMed
概括

斯芬哥辛-1-酸盐 (S1P) 通过S1PR1和Gβγ-PLCβ信号,激活含有白蛋白的重复8 (LRRC8) 通道. 这一途径与透性胀不同,揭示了LRRC8/VRAC激活的关键机制.

关键词:
在 GPCR 信号中,GPCR 发出信号.这就是为什么LRRC8在VRAC中,VRAC就是VRAC.斯芬戈辛-1-酸盐是一种

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