循环阿迪波金和早期类风湿性关节炎患者对治疗的反应
Georgios K Vasileiadis1, Yuan Zhang1, Tahzeeb Fatima1
1University of Gothenburg, Gothenburg, Sweden.
ACR open rheumatology
|November 4, 2024
概括
基线水平的阿迪波内克丁,丁和抵抗素不能预测早期类风湿性关节炎 (RA) 的治疗反应. 这项研究发现,这些阿迪波金与在48周内在RA患者中实现缓解之间没有联系.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性自身免疫性疾病,其特征是关节炎症.
- 阿迪波金 (adipokine),如阿迪波涅克丁 (adiponectin),勒丁 (leptin) 和抵抗素 (resistin),是脂肪组织产生的信号蛋白,在炎症中可能发挥作用.
- 了解早期RA治疗反应的预测因素对于优化患者的治疗结果至关重要.
研究的目的:
- 调查阿迪波涅克丁,莱普和抵抗素的基线水平与早期未经治疗的RA患者对抗风湿治疗的反应之间的关联.
- 为了确定这些阿迪波金能否预测实现临床缓解的可能性.
主要方法:
- 来自北欧风湿性疾病战略试验和注册试验的341名早期RA参与者的队列被随机分配给甲状腺素加上普雷尼索隆,科尔特利祖马布,阿巴特切普或托西利祖马布.
- 血阿迪波金水平 (阿迪波涅克丁,莱普丁,抵抗素) 在基线测量时使用酶相关免疫吸收剂测定.
- 缓解被定义为临床疾病活动指数 (CDAI) ≤2.8在48周,分析分层通过中位数阿迪波金水平和调整的Cox比例危险模型.
主要成果:
- 较高的基线抵抗水平与基线C-反应性蛋白 (CRP) 和关节胀的增加有关,但阿迪波内克丁和莱普没有.
- 在高于中位数和低于中位数基线阿迪波金水平的参与者之间,没有观察到平均CDAI或CDAI变化的显著差异.
- 基线阿迪波内克,莱普和抵抗素水平并没有显著预测48周内达到CDAI缓解的可能性 (所有P>0.25).
结论:
- 基线水平的阿迪波内克丁,莱普和抵抗素与早期RA患者治疗长达48周的临床缓解的可能性没有关联.
- 这些阿迪波金似乎不是可靠的生物标志物,用于预测这种早期RA队列的治疗反应.
- 可能需要进一步的研究来探索其他潜在的生物标志物或影响RA治疗结果的因素.
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