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奖励重新校准了人类杏仁体和海马体内内记录中的规则表示
Luis Manssuer1,2,3, Qiong Ding4, Yashu Feng5
1Department of Neurosurgery, RuiJin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. lrm48@cam.ac.uk.
Nature communications
|November 4, 2024
概括
杏仁体和海马体对于适应性行为转变至关重要. 这些区域的高频马活动信号奖励和惩罚,指导行为调整.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 计算神经科学是一种神经科学.
背景情况:
- 适应性行为依赖于当奖励规则发生变化时,刺激维度之间的反应转移.
- 之前关于转移的人类研究主要检查了前额叶皮质,使用间接的神经测量,如fMRI和病变数据.
研究的目的:
- 研究杏仁体和海马体在人类适应性行为转移中的作用,使用直接的内记录.
- 阐明基于规则的转移过程中奖励和惩罚信号的基础的神经机制.
主要方法:
- 在人类患者中,从杏仁体和海马体直接记录局部场势 (LFP) 的内记录.
- 在转换任务期间分析高频马活动 (HFG;60-250 Hz) 和低频相锁定 (3-5 Hz).
- 检查与奖励/惩罚信号和决策过程有关的神经活动.
主要成果:
- 奖励信号被编码在杏仁体和海马体HFG中,在"Win-Stay"轮班期间通过低频相锁定同步.
- 杏仁体HFG在"减班"规则更改期间编码了惩罚信号,表明它在启动轮班方面发挥了作用.
- 在非轮班试验中,海马体HFG抑制表明在防止干扰方面发挥作用,而杏仁体HFG则对刺激新奇性做出反应.
结论:
- 杏仁体和海马体在人类适应性行为转移中发挥着关键作用.
- 在这些地区,HFG活动和阶段锁定的特定模式与轮班期间的奖励/惩罚处理和决策有关.
- 这些发现增强了对杏仁体-海马体功能转移的理解,并对转移缺陷的神经精神疾病有影响.
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