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在重大抑郁症中脑pH值下降的死后证据:系统性审查和元分析

Hideo Hagihara¹, Tsuyoshi Miyakawa²

¹Division of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan. h-hagi@fujita-hu.ac.jp.

Translational psychiatry

|November 4, 2024

概括

重度抑郁症 (MDD) 与降低大脑pH值有关,特别是在出现反复发作和疾病持续时间较长的患者中. 这一发现可能表明大脑能量代谢的改变是神经精神疾病的常见因素.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
生物化学生物化学

背景情况:

大型抑郁症 (MDD) 与其他精神疾病 (如精神分裂症和双相情感障碍) 共享症状和脑部变化.
之前的研究指出,精神分裂症和双相情感障碍的脑pH值下降,与能量代谢的改变有关.
人类MDD患者的大脑pH值仍未得到充分研究.

研究的目的:

在MDD患者和对照人群中对死后大脑pH进行元分析.
为了研究大脑pH,抑郁情节复发和MDD的疾病持续时间之间的关系.
探索神经精神疾病潜在的跨诊断性内分类型.

主要方法:

使用随机效应模型对39个精选数据集 (790名MDD患者,957名对照) 的元分析.
分析pH值差异的ANOVA和ANCOVA,考虑诸如死后间隔,年龄和性别等共变量.
检查pH与疾病持续时间和发作复发的相关性.

主要成果:

与对照组相比,MDD患者的大脑pH值显著降低 (赫奇斯的g = -0.23,p = 0.0056).
不论性别,在患有复发期的患者中,降低pH值显著.
大脑pH与疾病持续时间有负相关性,女性的pH下降更大.

结论:

大脑pH值降低与MDD有关,特别是在出现重复发作和疾病持续时间长的情况下.
改变大脑能量代谢,导致pH值降低,可能代表MDD和其他神经精神疾病的跨诊断性内分类型.
进一步研究大脑pH值作为生物标志物是有必要的.

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