术后放射性治疗对甲状腺功能在患有差异化甲状腺癌的患者的长期影响
Fatma Avcı Merdin1, Asena Gökçay Canpolat2, Demet Çorapçıoğlu2
1Department of Endocrinology and Metabolism, Ankara University School of Medicine, Ankara, Türkiye. fatma_avci.md@hotmail.com.
Annals of nuclear medicine
|November 4, 2024
概括
对差异化甲状腺癌 (DTC) 的放射性 (RAI) 治疗可能会在治疗后暂时降低和副甲状腺激素 (PTH) 水平. 长期副甲状腺功能在DTC患者中保持不变,尽管建议早期监测.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 核医学就是核医学.
背景情况:
- 差异化甲状腺癌 (DTC) 往往是通过全额或亚全额甲状腺切除术来治疗的.
- 放射性 (RAI) 治疗是DTC的常见辅助治疗方法.
- 评估RAI对甲状腺功能的影响对于患者管理至关重要.
研究的目的:
- 评估术后RAI治疗对DTC患者甲状腺功能的影响.
- 为了比较带有和没有RAI治疗的患者的甲状腺上腺激素 (PTH) 和水平.
- 为了确定RAI剂量对副甲状腺功能的长期影响.
主要方法:
- 对226名DTC患者 (150名RAI,76名没有RAI) 的回顾性分析.
- 在手术前和RAI后5年内收集的临床数据和生化参数 (,PTH,,25-OH-D)
- 在RAI和非RAI组之间,并根据RAI剂量比较甲状腺功能标志物.
主要成果:
- 在PTH,或其他生化标志物中没有显著的术前差异.
- 接受较高RAI剂量 (≥3.7GBq) 的患者在RAI后1年表现出暂时较低的和PTH水平.
- 在5年内没有观察到生物化学参数的长期显著差异,其中有一例RAI后的正常血性甲状腺功能障碍症.
结论:
- 高剂量的RAI治疗可能会导致治疗后早期的和PTH水平暂时降低.
- 在DTC患者中,长期的甲状腺功能通常不会受到RAI治疗的影响,无论剂量如何.
- 建议在治疗后的早期阶段密切监测和PTH,以管理潜在的过渡性甲状腺功能低下症.
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