通过设计优化配方变量和工艺参数的质量,以提高纳米悬浮的通过皮肤递送
Hiep X Nguyen1,2, Nhi Y Le3, Chien N Nguyen4,5
1College of Pharmacy, California Northstate University, 9700 West Taron Drive, Elk Grove, CA, 95757, USA.
Drug delivery and translational research
|November 4, 2024
概括
这项研究优化了一个带有andrographolide纳米悬浮的器官凝,以提高通过皮肤递送药物的效果. 这种新型配方在体外显著改善了药物透到皮肤内和通过皮肤.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 纳米技术 纳米技术
背景情况:
- 安德罗格拉福利德是一种有希望的化合物,具有有限的生物可用性.
- 通过皮肤递送药物提供了一种系统管理的替代途径.
- 开发有效的局部配方对于增强通过皮肤透至关重要.
研究的目的:
- 制造,描述和优化一个含有andrographolide纳米悬浮的器官凝.
- 在体外增强andrographolide的通过皮肤递送药物.
- 确定纳米悬浮制剂的关键材料属性和工艺参数.
主要方法:
- 使用湿技术制备的andrographolide纳米悬浮.
- 通过设计质量方法来确定关键材料属性 (CMA) 和关键过程参数 (CPP).
- 开发和评估用于药物释放和皮肤透研究的Organogel配方.
主要成果:
- 优化的andrographolide纳米悬浮实现了所需的颗粒大小,多分散度指数,封装效率和药物加载.
- 与DMSO凝相比,Organogel配方显示药物透到和通过皮肤显著增强,与DMSO凝相比.
- 通过皮肤传递的关键参数,如累积透率,流量和透率系数明显改善.
结论:
- 安德罗格拉福利德纳米悬浮装载器官凝是一种有前途的系统,可以有效地通过皮肤递送药物.
- 优化的配方显著提高了andrographolide在体外通过皮肤递送的效果.
- 这种方法有可能通过局部应用提高andrographolide的治疗疗效.
相关概念视频
Factors Affecting Dissolution: Particle Size and Effective Surface Area
735
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
735
Factors Influencing Drug Absorption: Pharmaceutical Parameters
121
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
121
Drug Delivery: Overview
278
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
278
Factors Influencing Drug Absorption: Drug Dissolution
423
The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
423
Biopharmaceutics and Pharmacokinetics: Overview
1.9K
Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...
1.9K
Factors Influencing Drug Absorption: Physicochemical Parameters
237
The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
237


