患有先前孕期糖尿病的妇女患乳腺癌:一项基于全国登记的队列研究
Maria Hornstrup Christensen1,2,3, Christina Anne Vinter4,5,6, Thomas Bastholm Olesen4,6
1Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark. maria.hornstrup.christensen@rsyd.dk.
患有妊娠糖尿病 (GDM) 的女性不会面临患乳腺癌的风险增加. 然而,GDM史与乳腺癌诊断时的年龄较小有关,强调了早期检测的必要性.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 孕期糖尿病 (GDM) 是一种常见的妊娠并发症,与胰岛素抵抗有关.
- 胰岛素抵抗与乳腺癌有关,乳腺癌是女性最常见的癌症.
- 关于GDM与随后的乳腺癌风险之间的关联,存在相互矛盾的证据.
研究的目的:
- 调查GDM与发生乳腺癌风险之间的关联.
- 探索GDM对乳腺癌诊断时年龄的影响.
- 评估胰岛素抵抗严重程度和随后的糖尿病对乳腺癌风险的影响.
主要方法:
- 全国范围的,基于登记的丹麦妇女队列研究 (1997-2018).
- 由ICD-10代码定义的GDM和乳腺癌.
- 考克斯回归,逻辑回归和t测试用于统计分析.
主要成果:
- 在有或没有GDM的女性之间,整体乳腺癌风险没有显著差异 (aHR 0.96 [95% CI 0.83-1.12]).
- 患有GDM的女性在较年轻时被诊断出患有乳腺癌 (42.6岁对43.5岁,p=0.01).
- 胰岛素抵抗和随后的糖尿病的严重程度没有影响乳腺癌风险.
结论:
- 经过近12年的随访,在患有先前GDM的女性中,发生乳腺癌的风险没有增加.
- 不管更年期状态或胰岛素耐药性的严重程度,GDM史对乳腺癌风险没有影响.
- 优先考虑乳腺癌预防,早期检测和治疗对于所有女性来说都至关重要,无论GDM病史如何.
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