相关实验视频

Updated: Jun 8, 2025

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Published on: August 23, 2019

TM4SF4是一种诊断生物标志物,通过AKT通路加速乳头甲状腺癌的进展

Lizhi Lin^1,2, Jialiang Wen³, Tiansheng Xu⁴

¹Department of Surgery, Clinical Sciences Lund, Lund University, Lund, Sweden.

Cancer biology & therapy

|November 5, 2024

概括

这项研究显示TM4SF4在乳头甲状腺癌 (PTC) 中被上调,作为诊断标记物. 降低TM4SF4的调节抑制了PTC细胞生长和转移,这表明它在通过AKT途径在癌症进展中的作用.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物化学生物化学

背景情况:

乳头甲状腺癌 (PTC) 发病率正在上升,其潜在机制尚不清楚.
了解PTC进展中的新型分子参与者对于开发有效的诊断和治疗方法至关重要.

研究的目的:

为了研究TM4SF4在乳头甲状腺癌 (PTC) 进展中的生物学作用.
评估TM4SF4作为PTC的潜在诊断生物标志物.
探索TM4SF4介导的PTC进展中涉及的分子途径.

主要方法:

使用本地队列和人类蛋白质图谱数据进行差异基因表达分析和验证.
临床特征分析和接收器操作特征 (ROC) 曲线分析用于诊断标记物评估.
TM4SF4相关伙伴的相关性和丰富性分析,免疫透分析和体外实验 (TM4SF4敲击,AKT激活剂治疗).

主要成果:

TM4SF4在PTC中受到显著的上调,并作为一个强大的诊断标记物.
在PTC中,TM4SF4表达与细胞结合,凝聚力和免疫激活相关.
TM4SF4下调抑制PTC细胞增殖和转移,同时诱导细胞亡,可能通过AKT通路.

结论:

TM4SF4在乳头甲状腺癌的进展中起着致癌作用.
TM4SF4被确定为一种新的,有前途的PTC诊断生物标志物.
针对TM4SF4或AKT途径可能为PTC提供新的治疗策略.

关键词:

在 AKT AKT 里面.TM4SF4SF4 在线观看诊断生物标志物的生物标志物皮囊性甲状腺癌是什么?

更多相关视频

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

相关概念视频

PI3K/mTOR/AKT Signaling Pathway

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...

mTOR Signaling and Cancer Progression

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...