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在社区居住的非西班牙裔黑人中,神经纤维光和认知

Lubnaa Abdullah¹, Fan Zhang¹, James Hall¹

¹University of North Texas Health Science Center, Department of Family Medicine, Institute for Translational Research, Fort Worth, TX, USA.

Journal of Alzheimer's disease : JAD

|November 5, 2024

概括

血液中的神经纤维光链 (NfL) 与非西班牙裔黑人成年人的认知功能有关. 较高的NfL表明执行功能较差,这表明它可以早期检测神经退行.

科学领域:

神经科学是一个神经科学.
生物标志物生物标志物
认知老龄化认知老龄化

背景情况:

关于非西班牙裔黑人群体中神经丝光链 (NfL) 和认知功能的有限研究.
需要对神经退行症的血液生物标志物进行种族多样化的研究.

研究的目的:

调查血NfL水平与社区居住非西班牙裔黑人队列的认知结果之间的关联.
为了确定NfL是否能够在不同诊断类别中识别认知变化.

主要方法:

对HABS-HD研究中283名非西班牙裔黑人参与者的基线数据的分析.
使用Simoa平台测量血NfL.
对年龄,性别和教育进行调整的线性回归模型.

主要成果:

在总样本中发现了NfL和执行功能测试 (Trails A/B,FAS,Animals,Symbol Digit Substitution) 之间的显著关联.
较高的NfL水平与认知诊断,年龄较大和教育程度较低相关.
当按诊断组分层时,与执行功能的关联并不显着.

结论:

血NfL是一种与执行功能相关的非特异性标记物,反映了神经退行症对注意力,处理和生长能力的影响.
显而易见的神经退行性功能变化之前的认知处理变化的敏感指标NfL具有潜力.

关键词:

阿尔茨海默病的疾病阿尔茨海默病的疾病.生物标志物生物标志物美国黑人,美国黑人.多样性的多样性多样性的多样性非西班牙裔黑人.血的 nfL 在等离子体内

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