卡博普拉丁在肥胖患者的剂量
Cristina Ramírez-Roig1, Alberto Espuny-Miró1, Raquel Olmos-Jiménez1
1Pharmacy Service, Virgen de la Arrixaca University Clinical Hospital, Murcia, Spain.
概括
卡博普拉丁在肥胖患者的剂量显示,使用实际体重导致更多的毒性,特别是血小板缺血和中性质缺血. 然而,在卵巢和肺癌中的有效性在剂量方法之间没有显著差异.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 临床药房 临床药房
背景情况:
- 肥胖症在化疗剂量方面带来了挑战,特别是对于碳金.
- 精确的卡博普拉丁剂量对于平衡肥胖患者的疗效和毒性至关重要.
- 目前对肥胖个体的卡博普拉丁剂量的临床实践需要进一步调查.
研究的目的:
- 在一般大学医院的肥胖患者中描述卡博普拉丁剂量标准.
- 为了评估与不同卡博普拉丁剂量标准相关的毒性.
- 根据在主要瘤诊断中使用的剂量标准,评估卡博普拉丁治疗的有效性.
主要方法:
- 在2012年1月至2015年1月期间接受卡博普拉丁的肥胖患者 (BMI ≥30 kg/m2) 的观察性回顾性研究.
- 收集的数据包括患者的特征,疾病细节,碳烯的剂量方法 (Calvert的公式与GFR的Coccroft-Gault) 和毒性 (CTCAE v. 4.0).
- 通过对卵巢和非小细胞肺癌的总生存率和无进展生存率来评估有效性.
主要成果:
- 碳白金剂量使用卡尔维特公式与考克克罗夫特-高尔特法来估计GFR,使用实际体重 (ABW) 和理想调整体重 (IABW) 的比例相似.
- 在肥胖和糖尿病患者中,IABW更频繁地使用.
- 毒性,包括血小板缺血,中性缺血,GOT升高,低氧和肌痛,当卡博普拉丁用ABW剂量相比IABW时显著增加.
结论:
- 与IABW相比,使用ABW的肥胖患者的卡博普拉丁剂量与毒性增加有关.
- 尽管有毒性差异,但在卵巢和非小细胞肺癌的ABW和IABW剂量组之间没有观察到总生存或无进展生存的统计学上显著差异.
- 这些发现表明需要仔细考虑剂量策略,以减轻接受卡博普拉丁治疗的肥胖患者的毒性,同时保持治疗的有效性.
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