用于中风治疗的多:氧化应激调节的作用
Yusong Luo1,2, Ruolan Liu1,2, Guoqiang Yuan1,2
1Department of Neurosurgery, the Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730030, China. yuangq08@lzu.edu.cn.
Food & function
|November 5, 2024
概括
氧化压力有助于中风损伤. 本综述探讨了多和纳米材料如何用于对抗中风相关的氧化应激,以寻求潜在的新疗法.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 药理学 药理学是指药理学的学科.
背景情况:
- 卒中是导致残疾的主要原因,氧化应激 (OS) 是大脑损伤的关键因素.
- 多在实验中显示出抗氧化剂对中风的承诺,但临床翻译仍然有限.
- 纳米材料提供先进的药物输送能力,可能提高中风治疗中的多疗效.
研究的目的:
- 审查OS在中风病理学中的作用.
- 总结聚醇对中风引起的OS的抗氧化作用.
- 介绍纳米材料在输送抗氧化剂中风治疗中的应用和进展.
主要方法:
- 关于中风,OS,多和纳米材料的实验和临床研究的文献综述.
- 对大脑损伤中OS机制的分析.
- 评估多抗氧化活性及其对活性氧物种 (ROS) 的影响.
主要成果:
- 脑神经系统是中风引起的神经元损伤的关键调解者.
- 聚醇在临床前中风模型中显示出显著的ROS清除和神经保护作用.
- 基于纳米材料的输送系统显示了改善多生物可用性和中风治疗结果的潜力.
结论:
- 通过纳米材料介导的多提供了一种有希望的战略,以克服中风治疗的临床限制.
- 对纳米载体设计和聚醇选择的进一步研究对于有效的临床转化至关重要.
- 将纳米技术与抗氧化剂疗法相结合,具有显著的潜力,可以减轻与中风相关的脑损伤.
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