在耳鼻喉手术后出现刺激的德克斯梅德托米丁鼻喷雾:随机,双盲,受控试验的协议
Dan Wang1,2, Jing-Hui Hu1,2, Hai-Jing Shi1,2
1Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China.
在手术前使用德克斯梅德托米丁鼻喷雾剂,可以减少患有耳鼻腔外科手术的患者出现激动. 这项研究调查了它在预防这种常见但严重的术后并发症方面的有效性.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
背景情况:
- 出现动荡 (EA) 是全身麻醉后的一个常见并发症,特别是在耳鼻喉 (ENT) 手术中.
- EA与术后并发症的增加和患者的痛苦有关.
研究的目的:
- 评估手术前德克斯梅德托米丁鼻雾剂在减少经过耳鼻外科手术的成年患者出现动荡的发生率方面的疗效.
- 评估德克斯梅德托米丁对二次结果的影响,包括疼痛,睡眠障碍,焦虑和妄想.
主要方法:
- 一个随机的,双盲的,受控的试验,涉及160名预定接受耳鼻腔外科手术的成年患者.
- 患者在麻醉诱导前30分钟接受了100μg的德克斯梅德托米丁鼻雾或盐水安慰剂.
- 主要终点是EA的发病率,定义为Riker镇静激发量表≥5.5的得分.
主要成果:
- 这项研究是一项协议,结果正在等待.
- 该试验已在中国临床试验登记处注册 (ChiCTR2400086731).
结论:
- 预计这些发现将为改善ENT手术患者的麻醉治疗提供临床证据.
- 假设手术前的德克斯梅德托米丁鼻喷剂是管理出现动荡的有效干预措施.
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