发作中的情绪性并发症是由于发作诱导的皮质类固醇活性导致的
Renaud C Gom1,2, Antis G George1,2, Sydney A Harris1,2
1Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, T2N 4N1, Canada.
Neurobiology of stress
|November 5, 2024
概括
发作会通过增加皮质 (CORT) 来破坏情绪调节. 阻止CORT合成或其受体可以防止这些负面影响,为相关的情绪问题提供潜在的治疗方法.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 的研究研究.
背景情况:
- 经常与精神疾病同时发生,影响患者的生活质量.
- 发作活动会改变杏仁体内内内大麻素 (eCB) 信号的传递,这与情绪失调有关.
- 过度活跃的下丘脑-垂体-上腺 (HPA) 轴和皮质激素 (CORT) 的参与与和情绪处理有关.
研究的目的:
- 调查发作是否导致过度的CORT分泌.
- 确定CORT在eCB系统调节失调,恐惧记忆障碍和模型中的焦虑中的作用.
- 探索针对CORT途径的潜在治疗策略.
主要方法:
- 使用的杏仁体点燃了成年雄性长埃文斯老鼠.
- 采用全细胞补丁电生理学,行为范式和生物化学分析.
- 使用的药理工具包括一种CORT合成抑制剂 (美特拉) 和葡萄糖皮质/矿物质皮质受体对抗剂.
主要成果:
- 在点燃期间的发作后,血中CORT水平显著升高.
- 梅西拉的使用防止了发作诱导的CORT增加,胺下调和突触变化.
- 用抗体阻断CORT受体也可以预防慢性焦虑和恐惧记忆缺陷.
结论:
- 发作活动诱导CORT的高分泌,导致的情绪失调.
- 抑制CORT合成或阻止其受体可以减轻的负面情绪和认知后果.
- 准CORT途径是一个有希望的治疗途径,用于管理中的情绪并发症.
更多相关视频
09:49Using a Bipolar Electrode to Create a Temporal Lobe Epilepsy Mouse Model by Electrical Kindling of the Amygdala
Published on: June 29, 2022
2.4K
09:07Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
Published on: August 15, 2017
12.0K
相关概念视频
Seizures: Classification
303
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
303
Arteries of the Lower Limbs
178
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
178
Electroconvulsive Therapy
25
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
25
Physiology of Emotion
608
The physiology of emotions is a multifaceted process involving the autonomic nervous system, brain structures, hormones, and neurotransmitters. This intricate interplay dictates how emotions manifest in the body and influence behavior.
Autonomic Nervous System
The autonomic nervous system (ANS) plays a critical role in emotional responses by regulating involuntary physiological functions. It consists of two main components: the sympathetic and parasympathetic systems. The sympathetic system...
Autonomic Nervous System
The autonomic nervous system (ANS) plays a critical role in emotional responses by regulating involuntary physiological functions. It consists of two main components: the sympathetic and parasympathetic systems. The sympathetic system...
608
Bipolar Disorder
56
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
56
Hypothalamic-Pituitary Axis
59.3K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
59.3K
