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与凝血相关的基因对甲状腺癌的预后,免疫透,分期和药物敏感性产生影响
Yuxiao Sun1, Yifei Zhang1, Yuchuan Yang2
1Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Frontiers in immunology
|November 5, 2024
概括
凝血生物标志物D-二次体预测甲状腺癌 (THCA) 的侧侧淋巴结转移. 基于8个与凝血相关的基因的预后模型改善了个性化THCA治疗的风险分层.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物标志物发现发现
背景情况:
- 甲状腺癌 (THCA) 是最常见的内分泌恶性瘤.
- 凝血在THCA发育和进展中的作用仍然不清楚.
- 确定THCA转移的预测生物标志物对于患者管理至关重要.
研究的目的:
- 评估THCA患者侧侧淋巴结转移 (LLNM) 的D-二聚体的预测值.
- 为了确定与THCA预后相关的凝血相关基因 (CRG).
- 构建和验证基于CRG的THCA预后模型.
主要方法:
- 使用接收器操作特征 (ROC) 和后勤回归分析来评估D-二次元对LLNM的预测值.
- 对TCGA数据库的共识聚类分析确定了与凝血相关的分子亚型.
- 拉索回归选择了8个CRG来构建预后模型,然后进行风险分层,名录构造和RT-qPCR验证.
主要成果:
- D-二次体显示了LLNM的预测值 (AUC=0.656),高水平 (>0.065 mg/l) 是一个独立的预测因子.
- 使用8个CRG的预后模型有效地区分了高风险和低风险THCA患者 (P<0.001).
- 风险组之间观察到临床特征,基因突变,免疫透和药物敏感性的显著差异;8个CRG在THCA细胞系中过度表达.
结论:
- 凝血生物标志物,特别是D-二次体,在THCA中预测LLNM方面具有显著的潜力.
- 基于CRG开发的预后模型为THCA的风险分层和个性化治疗提供了一个新的工具.
- 这项研究为了解凝血在THCA中的作用提供了基础,并指导了针对性治疗的未来研究.
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