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肥胖对炎症性肠病患者从2008年到2020年的结果的影响
Andrej M Sodoma1, James R Pellegrini2, Samuel Greenberg3
1Internal Medicine, South Shore University Hospital, Bay Shore, USA.
Cureus
|November 5, 2024
概括
炎症性肠病 (IBD) 患者的肥胖增加了冲击,急性损伤和慢性类固醇使用的风险. 然而,肥胖的IBD患者患肠道抽的几率较低,这表明了复杂的相互作用.
科学领域:
- 胃肠病学和肝病学 胃肠学和肝病学
- 公共卫生和流行病学
- 临床医学 临床医学
背景情况:
- 美国肥胖的发病率和患病率不断上升,影响胃肠道疾病.
- 建议肥胖会加剧炎症性肠病 (IBD) 症状和治疗结果.
- 需要更好地了解肥胖对IBD患者发病率和死亡率的影响.
研究的目的:
- 调查肥胖对IBD患者发病率,死亡率,住院时间和费用的影响.
- 分析肥胖与非肥胖IBD患者的基线特征和并发症.
- 为了比较肥胖和非肥胖IBD患者队列之间的结果.
主要方法:
- 使用国家住院样本 (NIS) 数据库从2008年到2020年.
- 使用ICD-9/10代码和人口估计权重记录识别了18岁以上的IBD患者.
- 根据肥胖状况对患者进行分类,并使用加权后勤回归分析结果,并对混因素进行调整.
主要成果:
- 总共有2,105,418例IBD入院病例被分析;170,475人 (8.1%) 患有肥胖.
- 肥胖IBD患者年龄较大,并具有较高的并发症评分 (CCI),以及更普遍的心血管和代谢疾病.
- 肥胖的IBD患者患上冲击 (OR 1.228),急性心肌梗塞 (OR 1.692),急性损伤 (OR 1.187) 和慢性类固醇治疗 (OR 1.149) 的几率增加,但肠的几率较低 (OR 0.837).
结论:
- 肥胖为IBD患者带来了一系列复杂的并发症,增加了特定不良事件的风险.
- 肥胖IBD患者面临更高的冲击,急性损伤和慢性类固醇使用的几率.
- 在肥胖IBD患者中,肠的可能性降低,因此需要进一步调查肥胖在IBD中的多面性作用.
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