在目标范围指数中静脉血压时间与不良心血管结果之间的关联
Moran Li1, Song Zhao1,2, Shikai Yu1
1Department of Cardiology, Shanghai Tenth People's Hospital, School of medicine, Tongji University, Shanghai, China.
JACC. Advances
|November 5, 2024
概括
目标范围 (TTR) 中的最佳静心血压时间指标对于预测心血管事件至关重要. 早期控制,定义为3个月的TTR,显著影响长期重大不良心血管事件 (MACEs) 风险.
科学领域:
- 心脏病学 心脏病学
- 高血压管理 高血压管理
- 临床试验 临床试验
背景情况:
- 在目标范围 (TTR) 中计算SBP时间的最佳时间点和缩血压 (SBP) 范围缺乏共识.
- 了解TTR指标对于有效的高血压管理和心血管风险预测至关重要.
研究的目的:
- 调查各种SBP TTR指标与长期主要心血管不良事件 (MACE) 之间的关联.
- 为了确定最佳的SBP TTR参数来预测心血管结果.
主要方法:
- 综合性血压干预试验 (SPRINT) 的后期分析,涉及7134名参与者.
- 使用3个时间点和3个SBP范围计算SBPTTR指数;MACE (心脏病发作,中风,心力衰竭,心血管死亡) 是主要结局.
- 排除了最初2年发生事件的参与者;中位数随访时间为3.91年.
主要成果:
- 三个月的TTR 110-140 mmHg (3个月的TTR 110-140) 显示出与事件MACEs最强的关联.
- 0.65的TTR指数截止值确定了具有良好的早期SBP控制的患者.
- 较低的早期控制 (3 个月TTR ≤0.65),平均SBP (130-140 mmHg) 高,与MACE风险增加有关 (P=0.019).
结论:
- 3个月的TTR110-140 mmHg指数与非糖尿病高血压患者的2年MACE独立相关.
- 与平均SBP相结合的0.65的TTR指数截止值可以作为早期控制稳定性和晚期心血管风险评估的指标.
- 这一指标有助于根据早期血压控制识别患有心血管事件风险较高的患者.
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