怀孕相关静脉血栓栓塞症患者的不同血清代谢物,使用GC-MS/LC-MS非向代谢物分析
Yao Lv1,2,3, Xianjing Xie1,2,3, Hong Shi1,2,3
1The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Heliyon
|November 5, 2024
概括
非向的代谢学揭示了与怀孕相关的静脉血栓栓塞 (PA-VTE) 患者的不同代谢概况. 脂质,有机化合物和代谢途径的关键差异为新的诊断标记提供了潜在的潜力.
科学领域:
- 代谢学 代谢学 代谢学
- 生物化学 生物化学
- 产科 产科 产科 产科 产科
背景情况:
- 怀孕相关的静脉血栓栓塞 (PA-VTE) 是一个严重的健康问题.
- 了解PA-VTE的代谢基础对于改善诊断和治疗至关重要.
- 非定位代谢学提供了一种全面的方法来识别复杂疾病中的代谢变化.
研究的目的:
- 使用非向代谢学分析PA-VTE患者的血清代谢特征.
- 为了确定PA-VTE的潜在代谢生物标志物.
- 通过代谢分析,探索PA-VTE的病理生理机制.
主要方法:
- 使用气体染色体质谱法 (GC-MS) 和液体染色体质谱法 (LC-MS) 进行血清代谢物分析.
- 包括11名患有静脉瘤的孕妇 (实验组) 和11名健康的孕妇 (对照组).
- 鉴定和量化了广泛的代谢物,包括有机氧化合物和甲酸盐.
主要成果:
- 通过GC-MS识别了325种代谢物,通过LC-MS识别了3104种代谢物.
- 在PA-VTE患者和对照人群之间观察到脂质,有机化合物和其他代谢物水平的显著差异.
- 发现了诸如胺代谢,酸代谢和矿物质吸收等途径的改变.
结论:
- 代谢分析显示了与PA-VTE相关的明显代谢特征.
- 确定了潜在的生物标志物,包括脂肪酸和氨基酸 (例如,2-基氨基酸,棕乙烯胺).
- 研究结果提供了对PA-VTE病理生理学的见解,并可能有助于开发用于早期检测和治疗的新型诊断标记物.
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