在中年基本工作者中,COVID-19感染前后认知变化的表征
Zennur Sekendiz1, Olga Morozova2, Melissa A Carr1
1Department of Medicine-World Trade Center Health Program, Stony Brook University, Commack, NY, USA.
American journal of medicine open
|November 5, 2024
概括
COVID-19感染导致认知能力显著下降,相当于超过十年的衰老. 这种认知恶化在经历SARS-CoV-2感染 (PASC) 后急性后果的人中更为明显.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 之前关于COVID-19认知衰退的研究主要研究住院患者.
- 这项研究调查了SARS-CoV-2感染后基本工作人员的认知变化,包括那些患有SARS-CoV-2感染 (PASC) 后急性后果的人.
研究的目的:
- 为了确定COVID-19发病后是否出现认知衰退.
- 评估PASC患者的认知衰退是否更明显.
主要方法:
- 纵向不连续模型被用来分析来自276名COVID-19幸存者和217名对照者的认知数据.
- 在四个领域的认知表现被测量在疫情之前和之后.
- 参与者已经验证了COVID-19诊断和感染前和后的数据.
主要成果:
- 在COVID-19 (β = -0.168,P = .001) 之后观察到认知吞吐量显著下降.
- 认知变化相当于正常衰老的10.6年.
- 患有更严重COVID-19和报告PASC的个体的下降更为严重.
结论:
- COVID-19和PASC似乎导致临床相关的认知恶化.
- 研究结果强调了SARS-CoV-2感染的长期神经影响.
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