氨酸对近视儿童胸膜厚度的影响:一个元分析
Yaqi Yang1, Lijuan Wei1, Bo Wang1
1Ophthalmology Department, Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, China.
Frontiers in pharmacology
|November 5, 2024
概括
低剂量阿特罗平眼滴通过减少轴延长,有效地减缓了儿童近视的进展. 虽然最初会发生胆管厚,但它可能预测治疗成功的近视管理.
科学领域:
- 眼科医生 眼科 眼科
- 儿科眼科医生 儿科眼科医生
- 近视研究 近视研究
背景情况:
- 阿特罗平是预防和控制近视的公认治疗方法.
- 这一元分析的重点是氨酸对儿科近视的胸腔厚度 (ChT) 的影响.
研究的目的:
- 为了研究氨酸对近视儿童胸腔厚度 (ChT) 的影响.
- 评估阿特罗宾在控制轴长 (AL) 和标准化等效折射 (SER) 的有效性.
主要方法:
- 在Medline,Embase和Web of Science上进行了系统的文献搜索,截至2023年6月1日.
- 来自307只眼睛的数据使用STATA 12.0进行分析,重点关注ChT,AL和SER.
- 胸膜厚度是主要结局;AL和SER是次要结局.
主要成果:
- 阿特罗平在1个月后显示出胆道厚度的显著增加 (WMD,6.87毫米;P=0.049),但在以后的随访中没有.
- 在1,6和12个月 (P<0.05) 时,阿特罗平显著延迟了轴延长 (P<0.05).
- 通过最终的随访,阿特罗平在控制折射状态的进展方面表现出有效性.
结论:
- 有限的证据表明,0.01%的阿特罗宾在1个月后会诱导胆管厚,可能预测近视控制的有效性.
- 0.01%的氨酸有效控制近视的进展,这是SER和AL的变化所表明的.
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