RBPWorld用于探索跨物种RNA结合蛋白的功能和疾病关联
Jian-You Liao1,2, Bing Yang1, Chuan-Ping Shi1
1Department of Medical Research Center, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, 107 Yan Jiang West Road, Guangzhou, Guangdong 510120, China.
Nucleic acids research
|November 5, 2024
概括
RBPWorld是一个跨物种RNA结合蛋白 (RBPs) 的综合数据库. 它详细介绍了人类的RBPs,它们的目标,功能以及与疾病和病毒的联系,有助于研究.
科学领域:
- 分子生物学分子生物学
- 基因组学就是基因组学.
- 生物信息学是一种生物信息学.
背景情况:
- RNA结合蛋白 (RBPs) 是生理和病理过程中基因表达的关键调节者.
- 了解RBP功能及其疾病关联对于生物和医学研究至关重要.
研究的目的:
- 将EuRBPDB更新和扩展为RBPWorld,这是研究RNA结合蛋白的综合资源.
- 提供关于人类RBPs (hRBPs),其目标,调节途径和疾病关联的综合数据.
主要方法:
- 利用998个RNA结合域 (RBD) 和87个RBPome数据集,在445个物种中识别RBP.
- 分析了1515个交叉链接免疫沉降-seq和616个RNA-seq数据集,用于hRBP目标和调节作用.
- 系统地确定多功能RBP及其与疾病相关病毒的相互作用.
主要成果:
- 在各种物种中确定了1,393,413个RBPs,其中包括3030个人类RBPs (hRBPs).
- RBPWorld包含关于hRBP RNA目标,调节途径,替代拼接和838种与疾病相关的hRBP的数据.
- 发现了929个多功能RBP和970个hRBP与12种引起疾病的RNA病毒相互作用.
结论:
- RBPWorld是一个有价值的,用户友好的资源,用于探索RBP的多样化生物作用.
- 促进对RBP功能,疾病关联和与病原体相互作用的研究.
- 增强对跨物种和疾病背景下的RBPs基因调节的理解.
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