在库辛综合征中,风险较高和早期发病的玻璃眼
Yael Sharon1,2, Tzipora Shochat3, Yaron Rudman2,4
1Ophthalmology Department, Beilinson Hospital, Rabin Medical Center, Petah Tikva, Israel.
Acta ophthalmologica
|November 5, 2024
概括
患有库辛综合征 (CS) 的患者患有青光眼的风险明显更高. 与一般人群相比,这种眼睛疾病也往往在CS患者的年龄较小时发生.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 玻璃眼是全球不可逆转的失明的主要原因.
- 内源性库辛综合征 (CS) 是一种罕见的内分泌疾病,由长期暴露于过多的皮质醇引起.
- 在内源性CS患者中,青光瘤发病率和发病年龄之前尚未确定.
研究的目的:
- 为了确定内源性库辛综合征患者中青光眼的发病率.
- 为了比较CS患者与匹配的对照组的玻璃眼风险.
- 为了确定患有CS的个体中青光瘤发病的典型年龄.
主要方法:
- 进行了一项全国性的回顾性匹配队列研究.
- 确定了2000年至2023年间被诊断为内源性CS的患者.
- 脑脊髓病患者与基于年龄,性别,社会经济地位和BMI的对照人群进行1:5匹配.
主要成果:
- 总共分析了609名CS患者和3018名对照组.
- 在CS患者中,青光瘤的总体风险比CS患者高74% (HR=1.74,p=0.002).
- 与对照组 (66岁) 相比,眼在CS患者中平均年龄较小 (62岁).
- 在缓解期的患者和持久性高皮质醇症患者中都观察到增加的玻璃眼风险.
- 活跃的高皮质醇化与更早的青光眼发作有关.
结论:
- 内源性库辛综合征显著与眼风险增加有关.
- 在CS患者中,无论他们的缓解状态如何,都会增加青光瘤的风险.
- 与CS相关的玻璃眼往往在较年轻的年龄表现出来,而不是一般人群.
相关概念视频
Glaucoma: Overview
516
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
516
Angle Closure Glaucoma: Treatment
438
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
438
Open Angle Glaucoma: Treatment
395
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
395
Photoreceptors and Visual Pathways
5.7K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
5.7K
Adrenal Gland Disorders
1.4K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.4K


