对于静脉血栓栓塞的初级预防,使用他类药物
Zixin Wang1,2, Peng Zhang3, Jinhui Tian4
1Department of Breast Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.
The Cochrane database of systematic reviews
|November 5, 2024
概括
类药物可能会略有降低静脉血栓塞栓症 (VTE) 的发生率和死亡率,但这种影响可能太小而不会显著. 证据不足以证实对深静脉血栓塞 (DVT) 或肺栓塞 (PE) 的益处.
科学领域:
- 心血管医学 心血管医学
- 药理学 药理学是指药理学的学科.
- 证据综合 证据综合
背景情况:
- 静脉血栓塞栓症 (VTE),包括深静脉血栓症 (DVT) 和肺栓塞 (PE),影响全球数百万人.
- 胆固醇降低药物的他类药物具有血管保护和抗血栓性质.
- 类药物在一次性静脉瘤预防中的作用尚不清楚.
研究的目的:
- 评估他类药物的疗效和安全性,以预防VTE.
- 评估他类药物对VTE,DVT,PE,严重不良事件和死亡率的影响.
主要方法:
- 随机对照试验 (RCT) 的系统审查和元分析.
- 使用的Cochrane搜索方法,最后更新时间为2023年3月13日.
- 用于评估证据确定性的试验顺序分析 (TSA) 和GRADE方法.
主要成果:
- 27个具有122,601名参与者的RCT比较了他类药物与安慰剂或常规护理.
- 类药物显示了整体VTE发病率的潜在轻微减少 (OR 0.86,低确定性证据).
- 在DVT或PE发病率上没有明显的差异;观察到严重不良事件和死亡率略有减少.
结论:
- 类药物在初级VTE预防中可能提供边际益处,并降低所有原因的死亡率.
- 目前的证据受研究偏见和不准确性限制,需要进一步进行高质量的RCT.
- 特定的他类型,剂量和持续时间需要进一步调查才能得出最终的结论.
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